J Nonnewton Fluid Mech 40(3):271–280. Not affiliated The study of deformation and flow. doi: Brandsma RL, Rizvi SSH (2001) Effect of manufacturing treatments on the rheological character of Mozzarella cheese made from microfiltration retentate depleted of whey proteins1. On the other hand, there are also fluids that do not follow the Newtonian flow laws. Son WK, Youk JH, Lee TS, Park WH (2004) The effects of solution properties and polyelectrolyte on electrospinning of ultrafine poly(ethylene oxide) fibers. Fluids are different from solids, because fluids continuously deform when there is an applied stress, as shown in figure 1(b), while solids deform and then stop, as shown in figure 1(a). J Food Eng 79(3):1033–1047. stability) 4 of 65. [APPLICATION OF RHEOLOGY IN PHARMACY] [APPLICATION OF RHEOLOGY IN PHARMACY] [APPLICATION OF RHEOLOGY IN PHARMACY] Yao Xue Xue Bao. [wp_ad_camp_1]. Non-newtonian fluids. In general, rheological measurements on pharmaceutical materials are performed for the following reasons: Pharmaceutical materials range in consistency from fluid to solid. Rheol Acta 8(2):205–214. Rheology is the science of flow and deformation of matter. PMID: 14070257 No abstract available. Solids are said to have an ‘elastic’ response, and can resist Rheol Acta 47(5–6):621–642. doi: Korhonen M, Hellen L, Hirvonen J, Yliruusi J (2001) Rheological properties of creams with four different surfactant combinations - effect of storage time and conditions. doi: Macosko CW, Ocansey MA, Winter HH (1982) Steady planar extension with lubricated dies. Eur Polym J 46(2):324–335. doi: Haward SJ, Ober TJ, Oliveira MSN, Alves MA, McKinley GH (2012) Extensional rheology and elastic instabilities of a wormlike micellar solution in a microfluidic cross-slot device. Padmanabhan M, Kasehagen LJ, Macosko C (1996) Transient extensional viscosity from a rotational shear rheometer using fiber-windup technique. doi: Pipe CJ, Majmudar TS, McKinley GH (2008) High shear rate viscometry. The science of studying these types of unusual materials is called rheology. J Colloid Interface Sci 380(1):60–66. 2 of 9. Eur J Pharm Biopharm 87(2):227–35. Am J Physiol 261(5):G827–G832. Your email address will not be published. Edited by B. Warburton. Rheology Rheology is the science of the flow and deformation of matter under the effect of an applied force Matter : solid, liquid, gas Focus primarily on liquids and semisolids (e.g., creams, ointment, and gels) in this chapter Deformation: change of the shape and the size of a matter due to applied forces Experimental analysis. Int J Pharm 221(1–2):187–196. Rheology is therefore crucially important as it will directly affect the way a drug is formulated and developed, the quality of the raw and finished product, the drug efficacy, the way a patient adheres to the prescribed drug, and the overall healthcare cost. J Rheol 56(5):1279. doi: Wang Y-Y, Lai SK, Ensign LM, Zhong W, Cone R, Hanes J (2013) The microstructure and bulk rheology of human cervicovaginal mucus are remarkably resistant to changes in pH. J Nonnewton Fluid Mech 11(3–4):301–316. of Pharmaceutics, Vidyabharti College of Pharmacy, Camp road –Amravati- 444604 Affiliated to SGB Amravati University . J Nonnewton Fluid Mech 27(2):173–189. Many pharmaceutical processes such as new ingredient selections, formulation preparations, material packaging, and shelf storage are associated with a complex flow of materials. 1963 Jul;10:442-9 CONTD. Acta Technica 54:49–57. Rheol Acta 39(5):444–451. The rheology has a lot of applications in areas such as food, texture, personal care products, pharmacy, and polymers, among others. doi: Ferry JD (1980) Viscoelastic properties of polymers, 3rd edn. Rheologic consideration is of great importance in the study of the stability of pharmaceutical suspensions. Polym Eng Sci 11(2):174–176. doi: Raphaelides SN, Gioldasi A (2005) Elongational flow studies of set yogurt. doi: Allen A, Cunliffe WJ, Pearson JP, Sellers LA, Ward R (1984) Studies on gastrointestinal mucus. Rheology is a science that study the behavior of flow and deformation of materials in liquid state or soft solids under applications of stress or deformation to obtain the response to an applied force. J Rheol 45(1):115–138. doi: Haward S, Odell J, Berry M, Hall T (2011) Extensional rheology of human saliva. Rheology pdf 1. The majority of pharmaceutical materials are ointments, creams, pastes, and gels—all semisolids. They have to learn what to measure, how to measure, and what to do with the data. The resistance of the fluid to flow or movement. J Rheol 57(6):1533–1553. • Study of flow properties of liquids is important for pharmacist working in the manufacture of several dosage forms, viz., … doi: Celli JP, Turner BS, Afdhal NH, Ewoldt RH, McKinley GH, Bansil R, Erramilli S (2007) Rheology of gastric mucin exhibits a pH-dependent sol-gel transition. doi: Bhaskar KR, Gong D, Bansil R, Pajevic S, Hamilton JA, Turner BS, LaMont JT (1991) Profound increase in viscosity and aggregation of pig gastric mucin at low pH. The science of rheology is applied to the physics, chemistry, engineering, medicine, dentistry, pharmacy, biology and so on. This video explains you about various types of flow of fluids, plastic, pseudoplastic, dilatant flow in easier way. Definition of Rheology • Rheology is the science/physics that concerns with the flow of liquids and the deformation of solids. Rheol Acta 50(11–12):869–879. This is a preview of subscription content. All normal or Newtonian fluids (air, water, oil, honey) follow the same scientific laws. Ober TJ, Haward SJ, Pipe CJ, Soulages J, McKinley GH (2013) Microfluidic extensional rheometry using a hyperbolic contraction geometry. Haghighi M, Rezaei K, Labbafi M, Khodaiyan F (2011) On the formulation design and rheological evaluations of pectin-based functional gels. These non-Newtonian complex fluids, for example creams, pastes, ointments, gels, spray, and many other fluids, behave in a wide variety of ways. Adv Drug Delivery Rev 61(2):75–85. doi: Warburton B, Davis SS (1969) The oscillatory testing of pharmaceutical semi-solids using a transfer function analyser. Further Reading: External Links doi: Baldursdottir S, Kjoniksen A-L (2005) Rheological characterization and turbidity of riboflavin-photosensitized changes in alginate/GDL systems. Two scientists, Marcus Reiner and Eugene Bingham, founded the science after a meeting in the late 1920s at which they found out that they had a common interest in describing the flow properties of fluids. Am J Respir Crit Care Med 178(10):1033–1039. J Rheol 57(4):1065–1077. Elsevier, London. These non-Newtonian complex fluids, for example creams, pastes, ointments, gels, spray, and many other fluids, behave in a wide variety of ways. KW - rheology. 2007. to understand the fundamental nature of a system; for quality control of raw materials, final products, and manufacturing processes such as mixing, pumping, packaging, and filling; and. J Prosthet Dent 85(2):162–169, Kaschta JM, Münstedt H (2008) Measuring the elongational properties of polymer melts—a simple task? Polymer 45(9):2959–2966. In: Petsev DN (ed) Interface science and technology, vol 4, Emulsions: structure stability and interactions. This site uses Akismet to reduce spam. The uppermost layer has maximum velocity while the bottom layer is stationary. doi: Horter D, Dressman JB (2001) Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract. doi: Stokes JR, Davies GA (2007) Viscoelasticity of human whole saliva collected after acid and mechanical stimulation. Rheology Newtonian Faculty of Pharmacy, Omer Al-Mukhtar University, Tobruk, Libya. J Nanomater 2013:924947. doi: Eccleston GM, Hudson NE (2000) The use of a capillary rheometer to determine the shear and extensional flow behaviour of nasal spray suspensions. Examples of Complex Fluids in Pharmaceuticals. doi: Sridhar T, Tirtaatmadja V, Nguyen DA, Gupta RK (1991) Measurement of extensional viscosity of polymer-solutions. Oscillatory properties of carbopol gels. Describe the concept of stress. 12 ( 1 ):47–53: Allen a, Rasmussen HK rheology in pharmacy Hassager (! 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